the effect of glucocorticoid and glucocorticoid receptor interactions on brain, spinal cord, and glial cell plasticity

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ID: 201589
2017
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Abstract
Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse cell types react differently to GR activation. Stress/GCs induce structural plasticity in neurons, Schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate. While general nervous system plasticity is essential for adaptation and learning and memory, stress-induced plasticity is often maladaptive and contributes to neuropsychiatric disorders and neuropathic pain. In this brief review, we describe the evidence that stress/GCs activate GR to promote cell type-specific changes in cellular plasticity throughout the nervous system.
Reference Key
madalena2017neuralthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kathryn M. Madalena;Jessica K. Lerch
Journal tetrahedron
Year 2017
DOI
10.1155/2017/8640970
URL
http://dx.doi.org/10.1155/2017/8640970
Keywords
neurosciences neuropsychiatry biological psychiatry

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