ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors

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ID: 201539
2015
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Abstract
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses. Once internalized, these receptors may be recycled back to the plasma membrane by subunit-specific interactions with other proteins or by post-translational modifications such as phosphorylation. Alternatively, these receptors may be targeted for destruction by multiple degradation pathways in the cell. Ubiquitination, another post-translational modification, has recently emerged as a key signal that regulates the recycling and trafficking of glutamate receptors. In this review, we will discuss recent findings on the role of ubiquitination in the trafficking and turnover of ionotropic glutamate receptors and plasticity of excitatory synapses.
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goo2015frontiersubiquitin-dependent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marisa S Goo;Samantha L Scudder;Gentry N Patrick
Journal international journal of nanomedicine
Year 2015
DOI
10.3389/fnmol.2015.00060
URL
http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00060/full
Keywords
glutamate receptor ubiquitin synaptic plasticity neuropsychiatry biological psychiatry

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