phantom validation of tc-99m absolute quantification in a spect/ct commercial device

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2016
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Abstract
Aim. Similar to PET, absolute quantitative imaging is becoming available in commercial SPECT/CT devices. This study’s goal was to assess quantitative accuracy of activity recovery as a function of image reconstruction parameters and count statistics in a variety of phantoms. Materials and Methods. We performed quantitative Tc99m-SPECT/CT acquisitions (Siemens Symbia Intevo, Erlangen, Germany) of a uniform cylindrical, NEMA/IEC, and an anthropomorphic abdominal phantom. Background activity concentrations tested ranged: 2–80 kBq/mL. SPECT acquisitions used 120 projections (20 s/projection). Reconstructions were performed with the proprietary iterative conjugate gradient algorithm. NEMA phantom reconstructions were obtained as a function of the iteration number (range: 4–48). Recovery coefficients, hot contrast, relative lung error (NEMA phantom), and image noise were assessed. Results. In all cases, absolute activity and activity concentration were measured within 10% of the expected value. Recovery coefficients and hot contrast in hot inserts did not vary appreciably with count statistics. RC converged at 16 iterations for insert size > 22 mm. Relative lung errors were comparable to PET levels indicating the efficient integration of attenuation and scatter corrections with adequate detector modeling. Conclusions. The tested device provided accurate activity recovery within 10% of correct values; these performances are comparable to current generation PET/CT systems.
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gnesin2016computationalphantom Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Silvano Gnesin, Paulo Leite Ferreira, Jerome Malterre, Priscille Laub, John O. Prior, Francis R. Verdun
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Journal advanced functional materials
Year 2016
DOI
10.1155/2016/4360371
URL
http://dx.doi.org/10.1155/2016/4360371
Keywords
medical informatics computer applications to medicine

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