effect of the ascorbic acid treatment on the nadhd-positive myenteric neurons of diabetic rats proximal colon

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ID: 201247
2007
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Abstract
The aim of this work was to study the effect of the ascorbic acid on the myenteric neurons of diabetic rats proximal colon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabetic with ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments were submitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The group DA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05). Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreated diabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHd myenteric neurons of the proximal colon of diabetic rats.
O efeito do ácido ascórbico sobre neurônios mioentéricos do colo proximal de ratos diabéticos foi avaliado. Quinze ratos com 90 dias foram divididos nos grupos: controle, diabéticos e diabéticos tratados com ácido ascórbico (DA). Após 120 dias de tratamento diário com ácido ascórbico os segmentos intestinais foram submetidos à técnica histoquímica NADH-diaforase (NADHd). A densidade neuronal, em uma área de 14,11 mm² para cada segmento, e o perfil do corpo celular de neurônios (500 neurônios/grupo) foram avaliados. O grupo DA apresentou maior densidade neuronal (33.4 %) em relação aos animais diabéticos (p < 0.05). Da mesma forma, a área do corpo celular dos neurônios foi significativamente maior no grupo DA (17.3 %) quando comparado com o grupo diabético (p < 0.05). Concluímos que o acido ascórbico apresentou um efeito neuroprotetor sobre os neurônios mioentéricos NADHd do colo proximal de ratos diabéticos.
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zanoni2007brazilianeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jacqueline Nelisis Zanoni;Renata Virginia Fernandes Pereira;Priscila de Freitas
Journal current drug delivery
Year 2007
DOI
10.1590/S1516-89132007000100004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100004
Keywords
Diabetes ascorbic acid colon

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