near fatal asthma: clinical and airway biopsy characteristics

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ID: 201203
2012
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Abstract
Background. Inflammation and remodeling are integral parts of asthma pathophysiology. We sought to describe the clinical and pathologic features of near fatal asthma exacerbation (NFE). Methods. Bronchial biopsies were collected prospectively from NFE I subjects. Another NFE II group and a moderate severity exacerbation control group (ME II) were retrospectively identified—no biopsies obtained. Results. All NFE II (𝑛=9) subjects exhibited remodeling and significant inflammation (eosinophilic, neutrophilic). NFE II group (𝑛=37) had a significant history of prior intubation and inhaled corticosteroids usage compared to ME II group (𝑛=41). They also exhibited leukocytosis, eosinophilia, and longer hospitalization days. Conclusions. Remodeling, eosinophilic, and neutrophilic inflammation were observed in NFE. NFE is associated with prior intubation and inhaled corticosteroids usage.
Reference Key
barbers2012pulmonarynear Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Richard G. Barbers;Ilias C. Papanikolaou;Michael N. Koss;Ashish Patel;Elton Katagihara;Maggie Arenas;Khalid Chan;Colleen G. Azen;Om P. Sharma
Journal jurnal kimia (journal of chemistry)
Year 2012
DOI
10.1155/2012/829608
URL
http://dx.doi.org/10.1155/2012/829608
Keywords
diseases of the respiratory system

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