metastatic intimal sarcoma of the pulmonary artery sensitive to carboplatin-vinorelbine chemotherapy: case report and literature review

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ID: 200920
2018
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Abstract
Pulmonary artery intimal sarcoma (PAIS) is a very rare tumour with a very poor prognosis. In advanced stages, chemotherapy and radiotherapy are poorly efficient, and no standard chemotherapy guideline is currently available. Here, we report on a 37-year-old woman with PAIS initially treated with surgical resection who developed metastatic relapse refractory to anthracycline-based chemotherapy, then trabectedin, then pazopanib. The patient was then given carboplatin-vinorelbine chemotherapy. The treatment was well tolerated, and, rapidly, a CT scan showed an objective response that lasted 8 months despite the 4th therapeutic line. We review the literature and show that our case is the second one that provides evidence of the efficacy of platinum-vinorelbine regimens in this aggressive tumour.
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cantaloube2018casemetastatic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marie Cantaloube;Laurence Moureau-Zabotto;Lena Mescam;Audrey Monneur;Valeria Deluca;Jerome Guiramand;Delphine Perrot;François Bertucci
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2018
DOI
10.1159/000485740
URL
https://www.karger.com/Article/FullText/485740
Keywords
Chemotherapy Oncology including cancer and carcinogens tumors vinorelbineneoplasms

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