study of the effects of betaine and/or c-phycocyanin on the growth of lung cancer a549 cells in vitro and in vivo
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ID: 200915
2016
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Abstract
We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells. In vivo studies were performed in pathogen-free male nude rats injected with A549 cells in their right flank. Their daily food was supplemented with either betaine, C-PC, both, or neither. Compared to the control group, tumour weights and volumes were significantly reduced in either betaine- or C-PC-treated groups and no additional decrease was obtained with the combined treatment. This data indicates that C-PC and betaine alone may efficiently inhibit tumour growth in rats. The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro remains to be further confirmed in vivo. The reason behind the nature of their interaction is yet to be sought.
| Reference Key |
bingula2016journalstudy
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|---|---|
| Authors | ;Rea Bingula;Carmen Dupuis;Chantal Pichon;Jean-Yves Berthon;Marc Filaire;Lucie Pigeon;Edith Filaire |
| Journal | joule |
| Year | 2016 |
| DOI |
10.1155/2016/8162952
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| URL | |
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