IR-783 Labeling of a Peptide Receptor for 'Turn-On' Fluorescence Based Sensing.

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ID: 2009
2018
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Abstract
In this study, we examine a means for developing near-IR fluorescent sensors through streamlined, site-specific coupling with peptide-based receptors. As the penultimate step of solid-phase synthesis of a peptide-based receptor, we show a simple means of labeling the N' terminus with the near IR fluorophore IR-783 to afford a viable fluorescent sensor after cleavage from the resin. The proof-of-concept probe utilized a biotin mimetic peptide sequence as the receptive moiety. Here we revealed a "turn-on" fluorescence enhancement upon binding of the biotin mimetic probe to its intended streptavidin target. Not all peptide-receptive moieties tested were able to generate such an enhancement upon target binding, and as such, the rationale for the observed fluorescence response properties is discussed.
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kwak2018ir783chemosensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kwak, Eun-A;Kydd, LeNaiya;Lim, Butaek;Jaworski, Justyn;
Journal chemosensors
Year 2018
DOI
47
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Keywords
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