Romanian Wormwood ( L.): Physicochemical and Nutraceutical Screening.

Clicks: 302
ID: 20089
2019
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Abstract
species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02-0.1) > leaves (0.1-2.0) > stem (0.1-2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-o-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses.
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moac2019romanianmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Moacă, Elena-Alina;Pavel, Ioana Zinuca;Danciu, Corina;Crăiniceanu, Zorin;Minda, Daliana;Ardelean, Florina;Antal, Diana Simona;Ghiulai, Roxana;Cioca, Andreea;Derban, Mihnea;Simu, Sebastian;Chioibaş, Raul;Szuhanek, Camelia;Dehelean, Cristina-Adriana;
Journal molecules
Year 2019
DOI
E3087
URL
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