protective effects of aqueous extract of luehea divaricata against behavioral and oxidative changes induced by 3-nitropropionic acid in rats
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2015
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Abstract
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms. Luehea divaricata (L. divaricata), popularly known in Brazil as “açoita-cavalo,” may act as a neuroprotective agent in vitro and in vivo. We evaluated the hypothesis that the aqueous extract of L. divaricata could prevent behavioral and oxidative alterations induced by 3-NP in rats. 25 adult Wistar male rats were divided into 5 groups: (1) control, (2) L. divaricata (1000 mg/kg), (3) 3-NP, (4) L. divaricata (500 mg/kg) + 3-NP, and (5) L. divaricata (1000 mg/kg) + 3-NP. Groups 2, 4, and 5 received L. divaricata via intragastric gavage daily for 10 days. Animals in groups 3, 4, and 5 received 20 mg/kg 3-NP daily from days 8–10. At day 10, parameters of locomotor activity and biochemical evaluations were performed. Indeed, rats treated with 3-NP showed decreased locomotor activity compared to controls. Additionally, 3-NP increased levels of reactive oxygen species and lipid peroxidation and decreased ratio of GSH/GSSG and acetylcholinesterase activity in cortex and/or striatum. Our results suggest that rats pretreated with L. divaricata prior to 3-NP treatment showed neuroprotective effects when compared to 3-NP treated controls, which may be due to its antioxidant properties.
| Reference Key |
courtes2015evidence-basedprotective
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| Authors | ;Aline Alves Courtes;Letícia Priscila Arantes;Rômulo Pillon Barcelos;Ingrid Kich da Silva;Aline Augusti Boligon;Margareth Linde Athayde;Robson Luiz Puntel;Félix Alexandre Antunes Soares |
| Journal | ACS applied materials & interfaces |
| Year | 2015 |
| DOI |
10.1155/2015/723431
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| URL | |
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