effect of apheresis for abo and hla desensitization on anti-measles antibody titers in renal transplantation

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ID: 200427
2011
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Abstract
Desensitization strategies for ABO-incompatible renal transplants with plasma exchange (PE) or specific immunoadsorption (IA) decrease immunoglobulin levels. After recent measles outbreak and decreasing vaccination rates, we studied the impact of apheresis on anti-measles antibodies. Anti-measles antibodies were measured before desensitization, before transplantation and during followup in 12 patients with ABO incompatibility (2x PE only, 8x IA only, and 2x IA and PE) and 3 patients with donor-specific HLA antibodies (all PE). Patients received rituximab, IVIG, and standard immunosuppressive therapy. All patients had detectable anti-measles antibodies before desensitization (mean 3238 mU/l, range 560–8100). After 3–6 PE sessions, titers decreased significantly to 1710 mU/l (𝑃<0.05), in one patient to nondetectable values, while IA only maintained protective titers. After a median followup of 64 days, anti-measles antibodies returned to baseline in all patients. Immunity against measles was temporarily reduced by apheresis but remained detectable in most patients at time of transplantation. Desensitization maintains long-term protective immunity against measles.
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schnermarck2011journaleffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ulf Schönermarck, Teresa Kauke, Gundula Jäger, Antje Habicht, Thorsten Wendler, Joachim Andrassy, Markus Guba, Manfred Stangl, Michael Fischereder
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Journal clinical epigenetics
Year 2011
DOI
10.1155/2011/869065
URL
http://dx.doi.org/10.1155/2011/869065
Keywords
surgery

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