effect of apheresis for abo and hla desensitization on anti-measles antibody titers in renal transplantation
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2011
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Abstract
Desensitization strategies for ABO-incompatible renal transplants with plasma exchange (PE) or specific immunoadsorption (IA) decrease immunoglobulin levels. After recent measles outbreak and decreasing vaccination rates, we studied the impact of apheresis on anti-measles antibodies. Anti-measles antibodies were measured before desensitization, before transplantation and during followup in 12 patients with ABO incompatibility (2x PE only, 8x IA only, and 2x IA and PE) and 3 patients with donor-specific HLA antibodies (all PE). Patients received rituximab, IVIG, and standard immunosuppressive therapy. All patients had detectable anti-measles antibodies before desensitization (mean 3238 mU/l, range 560–8100). After 3–6 PE sessions, titers decreased significantly to 1710 mU/l (𝑃<0.05), in one patient to nondetectable values, while IA only maintained protective titers. After a median followup of 64 days, anti-measles antibodies returned to baseline in all patients. Immunity against measles was temporarily reduced by apheresis but remained detectable in most patients at time of transplantation. Desensitization maintains long-term protective immunity against measles.
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| Reference Key |
schnermarck2011journaleffect
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|---|---|
| Authors | ;Ulf Schönermarck;Teresa Kauke;Gundula Jäger;Antje Habicht;Thorsten Wendler;Joachim Andrassy;Markus Guba;Manfred Stangl;Michael Fischereder |
| Journal | clinical epigenetics |
| Year | 2011 |
| DOI |
10.1155/2011/869065
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| URL | |
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