lessons of als imaging: pitfalls and future directions — a critical review

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ID: 200224
2014
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Abstract
Background: While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. Objectives: To identify and discuss the common pitfalls in ALS imaging studies and to reflect on optimal study designs based on pioneering studies. Methods: A “PubMed”-based literature search on ALS was performed based on neuroimaging-related keywords. Study limitations were systematically reviewed and classified so that stereotypical trends could be identified. Results: Common shortcomings, such as relatively small sample sizes, statistically underpowered study designs, lack of disease controls, poorly characterised patient cohorts and a large number of conflicting studies, remain a significant challenge to the field. Imaging data of ALS continue to be interpreted at a group-level, as opposed to meaningful individual-patient inferences. Conclusions: A systematic, critical review of ALS imaging has identified stereotypical shortcomings, the lessons of which should be considered in the design of future prospective MRI studies. At a time when large multicentre studies are underway a candid discussion of these factors is particularly timely.
Reference Key
bede2014neuroimage:lessons Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Peter Bede;Orla Hardiman
Journal chemical engineering journal
Year 2014
DOI
10.1016/j.nicl.2014.02.011
URL
http://www.sciencedirect.com/science/article/pii/S2213158214000291
Keywords
MRI Biomarker amyotrophic lateral sclerosis pet diseases of the nervous system medical informaticsneurology

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