immunohistochemical expression of cxcr4 on breast cancer and its clinical significance

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ID: 200152
2015
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Abstract
Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance.
Reference Key
kishima2015analyticalimmunohistochemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marina Okuyama Kishima;Carlos Eduardo Coral de Oliveira;Bruna Karina Banin-Hirata;Roberta Losi-Guembarovski;Karen Brajão de Oliveira;Marla Karine Amarante;Maria Angelica Ehara Watanabe
Journal oriente moderno
Year 2015
DOI
10.1155/2015/891020
URL
http://dx.doi.org/10.1155/2015/891020
Keywords
neoplasms Oncology including cancer and carcinogenscytology tumors

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