Design and synthesis of fluorinated dendrimers for sensitive (19)F MRI.

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2015
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Ranked #40 of 103 articles by views in The Journal of organic chemistry

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Abstract
To achieve high sensitivity for (19)F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong (19)F NMR peak and short relaxation times. Eventually, an appreciably enhanced (19)F MRI at an extremely low concentration (18.5 μM) was achieved, which demonstrated the potential utility of such dendritic molecules in highly sensitive (19)F MRI.
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yu2015designthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yu, Weijiang;Yang, Yuqi;Bo, Shaowei;Li, Yu;Chen, Shizhen;Yang, Zhigang;Zheng, Xing;Jiang, Zhong-Xing;Zhou, Xin;
Journal The Journal of organic chemistry
Year 2015
DOI
10.1021/acs.joc.5b00294
URL
Keywords Keywords not found

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