Williamson Ether Synthesis with Phenols at a Tertiary Stereogenic Carbon: Formal Enantioselective Phenoxylation of β-Keto Esters.

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ID: 2000
2015
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Abstract
The enantioselective formation of α-aryloxy-β-keto esters is described for the first time. Lewis acid catalyzed enantioselective chlorination of β-keto esters and subsequent SN 2 reactions with phenols yielded α-aryloxy-β-keto esters with up to 96% ee. Favorskii rearrangement of α-chloro-β-keto esters was also found to give 1,2-diesters with slightly reduced enantiopurity.
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shibatomi2015williamsonchemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shibatomi, Kazutaka;Kotozaki, Manato;Sasaki, Nozomi;Fujisawa, Ikuhide;Iwasa, Seiji;
Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Year 2015
DOI
10.1002/chem.201502042
URL
Keywords Keywords not found

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