Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives.

Clicks: 310
ID: 19989
2019
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Abstract
A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound was the most active derivative, with an IC of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways.
Reference Key
alho2019synthesismolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alho, Daniela P S;Salvador, Jorge A R;Cascante, Marta;Marin, Silvia;
Journal molecules
Year 2019
DOI
E766
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Keywords Keywords not found

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