exosomes as carriers of alzheimer's amyloid-ß

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ID: 199616
2017
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Abstract
The intracerebral level of the aggregation-prone peptide, amyloid-ß (Aß), is constantly maintained by multiple clearance mechanisms, including several degradation enzymes, and brain efflux. Disruption of the clearance machinery and the resultant Aß accumulation gives rise to neurotoxic assemblies, leading to the pathogenesis of Alzheimer's disease (AD). In addition to the classic mechanisms of Aß clearance, the protein may be processed by secreted vesicles, although this possibility has not been extensively investigated. We showed that neuronal exosomes, a subtype of extracellular nanovesicles, enwrap, or trap Aß and transport it into microglia for degradation. Here, we review Aß sequestration and elimination by exosomes, and discuss how this clearance machinery might contribute to AD pathogenesis and how it might be exploited for effective AD therapy.
Reference Key
yuyama2017frontiersexosomes Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kohei Yuyama;Yasuyuki Igarashi
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2017
DOI
10.3389/fnins.2017.00229
URL
http://journal.frontiersin.org/article/10.3389/fnins.2017.00229/full
Keywords
alzheimer's disease exosome neuropsychiatry biological psychiatry

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