design and evaluation of split-ring resonators for aptamer-based biosensors
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2018
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Abstract
Split-ring resonators are electrical circuits, which enable highly sensitive
readout of split capacity changes via a measurement of the shift in the resonance
frequency. Thus, functionalization of the split allows the development of
biosensors, where selective molecular binding causes a change in permittivity
and therefore a change in split capacity. In this work, we present a novel
approach using transmission line theory to describe the dependency between
permittivity of the sample and resonance frequency. This theory allows the
identification of all relevant parameters of a split-ring resonator and thus
a target-oriented optimization process. Hereby all setup optimizations are
verified with measurements. Subsequently, the split of a resonator is
functionalized with aptamers and the sensor response is investigated. This
preliminary experiment shows that introducing the target protein results in
a shift in the resonance frequency caused by a permittivity change due to
aptamer-mediated protein binding, which allows selective detection of the
target protein.
| Reference Key |
reinecke2018journaldesign
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|---|---|
| Authors | ;T. Reinecke;J.-G. Walter;T. Kobelt;A. Ahrens;T. Scheper;S. Zimmermann |
| Journal | arabic literature in the post-classical period |
| Year | 2018 |
| DOI |
10.5194/jsss-7-101-2018
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| URL | |
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