intoxicação experimental por gentamicina em cães experimental gentamicin toxicosis in dogs
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ID: 199392
1997
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Abstract
A toxicose experimental por gentamicina foi estudada em 11 cães. Dez cães receberam 10mg/kg de gentamicina por via intramuscular, 3 vezes ao dia, durante 14 dias. Outro cão recebeu a mesma dose por 10 dias. Os cães foram submetidos à eutanásia e necropsiados no 11°, 15°-19°, 21°, 27° e 37° dias do experimento. Os principais sinais clínicos foram anorexia, apatia, poliuria, polidipsia, diarréia, vômito e oligúria. Os achados laboratoriais foram enzimúria, cilindrúria, azotemia e isostenúria. As lesões macroscópicas eram restritas aos rins, que estavam acentuadamente pálidos, tumefeitos e macios. Dois cães desenvolveram edema perirrenal discreto. Ao exame histológico do rim, dez cães tinham necrose tóxica aguda restrita aos túbulos contorcidos proximais. Regeneração das células epiteliais desses túbulos foi observada nos rins de todos os cães, principalmente na cortical externa, variando de mínima a acentuada e associada a dilatação acentuada da luz tubular. Aos 37 dias os rins apresentavam-se morfologicamente recuperados. Não foram observadas lesões glomerulares, nem lesões extra-renais de uremia. Concluiu-se que a gentamicina, na dose e frequência administradas, foi tóxica para todos os cães, causando necrose tubular renal aguda com subsequentes graus variados de regeneração tubular.
An experiment on gentamicin toxicosis was carried out in 11 dogs. Ten dogs received 10 mg/kg intramuscularly 3 times a day for 14 days and another dog the same dosage for 10 days. All dogs were euthanatized and necropsied at the 11th, 15th-19th, 21th, 27th, and 37th day of the experiment. Main clinical signs were: loss of appetite, apathy, polyuria, polydpsia, diarrhea, vomit and oliguria. Laboratory findings included enzymuria, cylindruria, azotemia and isosthenuria. Gross lesions were restricted to the kidneys, these were pallid, swollen and soft. Two dogs developed mild perirenal edema. Histologically, tubular necrosis, restricted to the proximal convoluted tubules, was observed in the kidneys of 10 dogs. In the kidneys of all dogs there was regeneration of epithelial cells of those tubules; this change occurred mainly in the external cortex, varied from minimal to marked, and was associated to marked tubule dilation. At the 37th day of the experrment, the kidneys have their normal morphology restored. Neither glomerular lesions nor extrarenal lesions related to uremia were observed. It is concluded that gentamicin was toxic to dogs when administered in the dosis and frequency stated above and induced acute renal tubular necrosis with subsequent variable degrees of regeneration.
An experiment on gentamicin toxicosis was carried out in 11 dogs. Ten dogs received 10 mg/kg intramuscularly 3 times a day for 14 days and another dog the same dosage for 10 days. All dogs were euthanatized and necropsied at the 11th, 15th-19th, 21th, 27th, and 37th day of the experiment. Main clinical signs were: loss of appetite, apathy, polyuria, polydpsia, diarrhea, vomit and oliguria. Laboratory findings included enzymuria, cylindruria, azotemia and isosthenuria. Gross lesions were restricted to the kidneys, these were pallid, swollen and soft. Two dogs developed mild perirenal edema. Histologically, tubular necrosis, restricted to the proximal convoluted tubules, was observed in the kidneys of 10 dogs. In the kidneys of all dogs there was regeneration of epithelial cells of those tubules; this change occurred mainly in the external cortex, varied from minimal to marked, and was associated to marked tubule dilation. At the 37th day of the experrment, the kidneys have their normal morphology restored. Neither glomerular lesions nor extrarenal lesions related to uremia were observed. It is concluded that gentamicin was toxic to dogs when administered in the dosis and frequency stated above and induced acute renal tubular necrosis with subsequent variable degrees of regeneration.
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dantas1997cinciaintoxicao
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| Authors | ;Antônio Flávio Medeiros Dantas;Glaucia Denise Kommers;Carla Rosane de Aguiar Hennemann |
| Journal | Trials |
| Year | 1997 |
| DOI |
10.1590/S0103-84781997000300015
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