invasive aspergillosis: results of multicenter study
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Abstract
We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequate
therapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.
| Reference Key |
klimko2014onkogematologiinvasive
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| Authors | ;N. N. Klimko;O. V. Shadrivova;S. N. Khostelidi;E. A. Desyatik;Yu. V. Borzova;R. M. Chernopyatova;E. V. Shagdileeva;A. G. Volkova;M. O. Popova;I. S. Zyuzgin;O. S. Ruzhinskaya;O. Ye. Ryabykina;N. V. Medvedeva;A. S. Kolbin;E. G. Boychenko;T. S. Bogomolova;S. M. Ignatieva;L. S. Zubarovskaya;B. V. Afanasiev |
| Journal | basic and clinical neuroscience |
| Year | 2014 |
| DOI |
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