invasive aspergillosis: results of multicenter study

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ID: 199322
2014
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Ranked #19 of 24 articles by views in basic and clinical neuroscience

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Abstract

We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequate
therapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.

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klimko2014onkogematologiinvasive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;N. N. Klimko;O. V. Shadrivova;S. N. Khostelidi;E. A. Desyatik;Yu. V. Borzova;R. M. Chernopyatova;E. V. Shagdileeva;A. G. Volkova;M. O. Popova;I. S. Zyuzgin;O. S. Ruzhinskaya;O. Ye. Ryabykina;N. V. Medvedeva;A. S. Kolbin;E. G. Boychenko;T. S. Bogomolova;S. M. Ignatieva;L. S. Zubarovskaya;B. V. Afanasiev
Journal basic and clinical neuroscience
Year 2014
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