propofol in combination with remifentanil for cesarean section: placental transfer and effect on mothers and newborns at different induction to delivery intervals

Clicks: 428
ID: 199205
2017
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #9 of 196 articles by views in spermova

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 196 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Objective: This study aims to describe the administration of propofol in combination with remifentanil for the induction of general anesthesia during cesarean section (CS). Our aim was to evaluate its impact on the drug concentrations of the maternal and neonatal blood at different induction of anesthesia to delivery (I–D) intervals as well as its effect on newborns. Materials and methods: In this double-blind randomized controlled study, patients undergoing elective CS were administered anesthesia at short (n = 20) or long (n = 20) I–D intervals. Anesthesia was induced with 1 mg/kg propofol and 1 μg/kg remifentanil and maintained by continuous infusion of 3 mg/kg/h propofol and 7 μg/kg/h remifentanil. Results: The mean plasma propofol concentrations at delivery in the maternal arterial (MA) blood and the fetal umbilical arterial (UA) and venous (UV) blood in the short I–D interval group were 1.91, 1.17, and 0.51 μg/mL, respectively, while those in the long I–D interval group were 1.57, 1.07, and 0.61 μg/mL, respectively. The mean plasma remifentanil concentrations at delivery in the MA, UA, and UV in the short I–D interval group were 2.25, 1.43, and 0.65 ng/mL, respectively, and those in the long I–D interval group were 1.96, 1.25, and 0.75 ng/mL, respectively. There were no statistically significant differences in the neonatal Apgar scores and neurological adaptive capacity scores between the two groups. Conclusions: It is safe to administer propofol in combination with remifentanil by continuous infusion after the bolus dose for the induction of anesthesia during cesarean section. Prolonging the I–D interval within a certain limit will not have any significant influence on the fetus.
Reference Key
hu2017taiwanesepropofol Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Liguo Hu;Jianhui Pan;Shantang Zhang;Jinjing Yu;Keqiang He;Shuhua Shu;Ruiting Wang
Journal spermova
Year 2017
DOI
10.1016/j.tjog.2016.09.010
URL
http://www.sciencedirect.com/science/article/pii/S102845591730150X
Keywords
general anesthesia propofol

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.