Solid Phase Stepwise Synthesis of Polyethylene Glycols.

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ID: 1990
2017
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Ranked #30 of 117 articles by views in Chemistry (Weinheim an der Bergstrasse, Germany)

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Abstract
Polyethylene glycol (PEG) and derivatives with eight and twelve ethylene glycol units were synthesized by stepwise addition of tetraethylene glycol monomers on a polystyrene solid support. The monomer contains a tosyl group at one end and a dimethoxytrityl group at the other. The Wang resin, which contains the 4-benzyloxy benzyl alcohol function, was used as the support. The synthetic cycle consists of deprotonation, Williamson ether formation (coupling), and detritylation. Cleavage of PEGs from solid support was achieved with trifluoroacetic acid. The synthesis including monomer synthesis was entirely chromatography-free. PEG products including those with different functionalities at the two termini were obtained in high yields. The products were analyzed with ESI and MALDI-TOF MS and were found close to monodispersity.
Reference Key
khanal2017solidchemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khanal, Ashok;Fang, Shiyue;
Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Year 2017
DOI
10.1002/chem.201703004
URL
Keywords Keywords not found

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