synthesis of aminoglycoside-2′-o-methyl oligoribonucleotide fusions
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ID: 198878
2017
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Abstract
Phosphoramidite building blocks of ribostamycin (3 and 4), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified solid support, were applied for the preparation of aminoglycoside-2′-O-methyl oligoribonucleotide fusions. The fusions were used to clamp a single strand DNA sequence (a purine-rich strand of c-Myc promoter 1) to form triple helical 2′-O-methyl RNA/DNA-hybrid constructs. The potential of the aminoglycoside moieties to stabilize the triple helical constructs were studied by UV-melting profile analysis.
| Reference Key |
granqvist2017moleculessynthesis
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|---|---|
| Authors | ;Lotta Granqvist;Andrzej Kraszewski;Ville Tähtinen;Pasi Virta |
| Journal | Journal of ethnopharmacology |
| Year | 2017 |
| DOI |
10.3390/molecules22050760
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| URL | |
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