detection of autoantibodies against 3,5,3′-triiodothyronine in a hyperthyroid patient (a case report).

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ID: 198646
1991
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Abstract
A 35-year-old female patient was evaluated for thyroid function and was found to be hyperthyroid clinically and by laboratory tests. During the course of treatment with neomercazole, she developed a bizarre picture with consistently low T3 levels irrespective of her clinical thyroid status and other laboratory tests like serum T4 and TSH levels. The serum of the patient when analysed for the presence of autoantibodies was positive for those against T3. The presence of T3 autoantibodies was confirmed by other laboratory techniques like assessment of blank values in radioimmunoassay, binding of T3-125I to isolated gamma globulin and starch gel electrophoresis. Autoantibodies were found to be present only against T3 and not against. T4 The affinity constant of T3 antibodies was 4 x 10(9) lit. mol-1 as determined by Scatchard plot analysis while total binding capacity was 23 x 10(-11) mol/L.
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l1991journaldetection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Joseph L;Desai K;Mehta M
Journal international islamic university malaysia engineering journal
Year 1991
DOI
DOI not found
URL
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=1;spage=44;epage=8;aulast=Joseph
Keywords
analysis adult case report human female immunology triiodothyronine autoantibodies comparative study hyperthyroidism thyroxine

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