isolation, identification and antimicrobial activities of two secondary metabolites of talaromyces verruculosus

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ID: 198458
2012
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Abstract
From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Reference Key
yang2012moleculesisolation, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xin-Juan Yang;Bao-Fu Qin;Ying Wang;Rui Yang;Dong-Dong Chen;Fang Miao;Le Zhou
Journal Journal of ethnopharmacology
Year 2012
DOI
10.3390/molecules171214091
URL
http://www.mdpi.com/1420-3049/17/12/14091
Keywords
Antimicrobial activity Organic Chemistry isocoumarin stellera chamaejasme l

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