trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme ii by n-allyl and n-propyl oxamates and their effects on intact epimastigotes
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ID: 198081
2004
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Abstract
N-allyl (NAOx) and N-propyl (NPOx) oxamates were designed as inhibitors of alpha-hydroxyacid dehydrogenase (HADH) isozyme II from Trypanosoma cruzi. The kinetic studies showed that NAOx and NPOx were competitive inhibitors of HADH-isozyme II (Ki = 72 µM, IC50 = 0.33 mM and 70 µM, IC50 = 0.32 mM, respectively). The attachment of the allylic and propylic chains to nitrogen of the competitive inhibitor oxamate (Ki = 0.91 mM, IC50 = 4.25 mM), increased 12.6 and 13-folds respectively, the affinity for T. cruzi HADH-isozyme II. NAOx and NPOx were selective inhibitors of HADH-isozyme II, because other T. cruzi dehydrogenases were not inhibited by these substances. Since HADH-isozyme II participates in the energy metabolism of T. cruzi, a trypanocidal effect can be expected with these inhibitors. However, we were not able to detect any trypanocidal activity with these oxamates. When the corresponding ethyl esters of N-allyl (Et-NAOx) and N-propyl (Et-NPOx) oxamates were tested as a possible trypanocidal prodrugs, in comparison with nifurtimox and benznidazole, the expected trypanocidal effects were obtained.
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chena2004memriastrypanosoma
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| Authors | ;Miguel A Chena;Silvia Elizondo-Jiménez;Lorena Rodríguez-Páez;Benjamín Nogueda-Torres;Isabel Baeza-Ramírez;Carlos Wong-Ramírez |
| Journal | kurdistan journal of applied research |
| Year | 2004 |
| DOI |
10.1590/S0074-02762004000800009
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