Cichorins D-F: Three New Compounds from and Their Biological Effects.

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ID: 198025
2020
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Abstract
L., (chicory) is employed in various traditional medicines to treat a wide range of diseases and disorders. In the current investigation, two new naphthalane derivatives viz., cichorins D () and E (), along with one new anthraquinone cichorin F (), were isolated from In addition, three previously reported compounds viz., β-sitosterol (), β-sitosterol β-glucopyranoside (), and stigmasterol () were also isolated from Their structures were established via extensive spectroscopic data, including 1D (H and C) and 2D NMR (COSY, HSQC and HMBC), and ESIMS. Cichorin E () has a weak cytotoxic effect on breast cancer cells (MDA-MB-468: IC: 85.9 µM) and Ewing's sarcoma cells (SK-N-MC: IC: 71.1 µM); cichorin F () also illustrated weak cytotoxic effects on breast cancer cells (MDA-MB-468: IC: 41.0 µM and MDA-MB-231: IC: 45.6 µM), and SK-N-MC cells (IC: 71.9 µM). Moreover compounds - did not show any promising anthelmintic effects.
Reference Key
khan2020cichorinsmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khan, Muhammad Farooq;Nasr, Fahd A;Noman, Omar M;Alyhya, Nouf Abdulaziz;Ali, Iftikhar;Saoud, Mohamad;Rennert, Robert;Dube, Mthandazo;Hussain, Wahid;Green, Ivan R;Basudan, Omer Ahmed M;Ullah, Riaz;Anazi, Shamsa Hilal;Hussain, Hidayat;
Journal molecules
Year 2020
DOI
E4160
URL
Keywords
Asteraceae natural product anthraquinone cichorium intybus cytotoxic effects naphthalene

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