immediate effects of maternal deprivation on the (re)activity of the hpa axis differ in cd1 and c57bl/6j mouse pups

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ID: 197624
2014
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Abstract
The postnatal development of the mouse is characterised by a period of hypo-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to mild stressors. Maternal deprivation (MD) during this period can disrupt the quiescence of the HPA-axis. The present study examined the influence of strain (outbred CD1 versus inbred C57BL/6J mice) on some central and peripheral components of the HPA-axis in neonatal mice (5 day-old) in the presence of their mother or after 24 h MD (on postnatal day 4) under basal or mild stressful conditions. In the presence of the dam, adrenal corticosterone (CORT) secretion was low in both mouse strains. Compared to CD1 mice, C57BL/6J had lower CORT levels associated with higher ACTH levels and ACTH/CORT ratio (i.e., lower adrenal sensitivity to ACTH), and higher glucocorticoid receptor (GR) mRNA expression in the paraventricular nucleus. Although MD disinhibited the HPA-axis in both strains as reflected by increased basal CORT and ACTH, we found a strain-dependent pattern. MD increased CORT more in C57BL/6J, compared to CD1 mice, together with a lower ACTH/CORT ratio (i.e., higher adrenal sensitivity to ACTH), while GR mRNA was no longer different in the two strains. However, this increased adrenal sensitivity in maternally deprived C57BL/6J mice was not reflected in their CORT response to a subsequent novelty stressor, possibly due to a MD-induced ceiling effect in their steroidogenic capacity.In conclusion, the immediate outcome of MD depends on the genetic background of the mother-infant dyad, suggesting that maybe also the outcome in later-life cannot be generalized. genetic background of the mother-infant dyad, predicting that the outcome in later-life cannot be generalized.
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daskalakis2014frontiersimmediate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nikolaos P Daskalakis;Nikolaos P Daskalakis;Nikolaos P Daskalakis;Leo eEnthoven;Edwige eSchoonheere;Edo Ronald De Kloet;Edo Ronald De Kloet;Melly S Oitzl;Melly S Oitzl
Journal aip advances
Year 2014
DOI
10.3389/fendo.2014.00190
URL
http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00190/full
Keywords
corticosterone genetic acth crh clinical endocrinology

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