cytoprotective activity of glycyrrhizae radix extract against arsenite-induced cytotoxicity

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ID: 197354
2008
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Abstract
Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated the effect of licorice on arsenite (As)-induced cytotoxicity in H4IIE cells, a rat hepatocyte-derived cell line. Cell viability was significantly diminished in As-treated H4IIE cells in a time and concentration-dependent manner. Furthermore, results from flow cytometric assay and DNA laddering in H4IIE cells showed that As treatment induced apoptotic cell death by activating caspase-3. Licorice (0.1 and 1.0 mg ml−1) treatment significantly inhibited cell death and the activity of caspase-3 in response to As exposure. These results demonstrate that licorice induced a cytoprotective effect against As-induced cell death by inhibition of caspase-3.
Reference Key
kim2008evidence-basedcytoprotective Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sang Chan Kim;Sook Jahr Park;Jong Rok Lee;Jung Cheol Seo;Chae Ha Yang;Sung Hui Byun
Journal ACS applied materials & interfaces
Year 2008
DOI
10.1093/ecam/nem014
URL
http://dx.doi.org/10.1093/ecam/nem014
Keywords
Other systems of medicine

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