Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples.

Clicks: 305
ID: 197035
2020
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Abstract
Vibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical "fingerprint" with a unique signature profile. Nuclear magnetic resonance (NMR) spectroscopy and an array of mass spectrometry (MS) techniques provide selectivity and specificity for screening metabolites, but demand costly instrumentation, complex sample pretreatment, are labor-intensive, require well-trained technicians to operate the instrumentation, and are less amenable for implementation in clinics. The potential for vibration spectroscopy techniques to be brought to the bedside gives hope for huge cost savings and potential revolutionary advances in diagnostics in the clinic. We discuss the utilization of current vibrational spectroscopy methodologies on biologic samples as an avenue towards rapid cost saving diagnostics.
Reference Key
hackshaw2020vibrationalmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hackshaw, Kevin V;Miller, Joseph S;Aykas, Didem P;Rodriguez-Saona, Luis;
Journal molecules
Year 2020
DOI
E4725
URL
Keywords
spectroscopy Biomarker Raman Spectroscopy metabolites fingerprinting diagnostics infrared spectroscopy vibrational spectroscopy biofluid

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