The Protective Effect of Rosewater against DNA Damages and Oxidant and Antioxidant Parameters of Rats Exposed to Chlorpyrifos Ethyl.

The aim of this study was to determine both the protective effect of rose water (RW) against DNA damage in the tissues of rats exposed to chlorpyrifos-ethyl (CPE) and RW's effect on the oxidant and antioxidant levels in the blood serum and brain tissues of those same rats.In this experimental study, 32 mature male wistar albino rats were divided into 4 groups: group I, control; group II, CPE; group III, RW; and group IV, CPE+RW. The parameters of DNA tail intensity and DNA tail moment were analysed in blood samples by comet assay. Glutathione S-transferase (GST), catalase (CAT), and malondialdehyde (MDA) levels in brain tissues were examined. In blood serum, the levels of melatonin (MT) from 3-nitrotyrosine (3-NT) were determined.In the CPE+RW group, the MDA and 3-NT levels in the brain tissues were significantly reduced (p<0.001), while the MT, GST, and CAT levels were significantly higher (p<0.001) compared to those of the CPE group. When the control and RW groups were compared, the CAT, GST, and MT levels were significantly higher (p<0.001) in the RW group, while the MDA and 3-NT levels were significantly lower (p<0.001).In rats, RW had positive effects on oxidant damage created by CPE. Both the DNA tail intensity and DNA tail moment in the CPE group were significantly higher (P<0.001) compared to those measures for the control group.