alterations of the erythrocyte membrane during sepsis

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ID: 196752
2012
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Abstract
Erythrocytes have been long considered as “dead” cells with transport of oxygen (O2) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. In this paper, we review the alterations in the erythrocyte membrane observed in critically ill patients and the influence of these alterations on the microcirculatory abnormalities observed in such patients. An understanding of the mechanisms of RBC rheologic alterations in sepsis and their effects on blood flow and on oxygen transport may be important to help reduce morbidity and mortality from severe sepsis.
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serroukh2012criticalalterations Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yasmina Serroukh;Sarah Djebara;Christophe Lelubre;Karim Zouaoui Boudjeltia;Patrick Biston;Michael Piagnerelli
Journal Chemosphere
Year 2012
DOI
10.1155/2012/702956
URL
http://dx.doi.org/10.1155/2012/702956
Keywords
critical care first aid intensive care medical emergencies

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