Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish.

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ID: 19667
2019
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Abstract
Spinal cord patterning is orchestrated by multiple cell signalling pathways. Neural progenitors are maintained by Notch signalling, whereas ventral neural fates are specified by Hedgehog (Hh) signalling. However, how dynamic interactions between Notch and Hh signalling drive the precise pattern formation is still unknown. We applied the PHRESH (otoconvertible porter of ignalling istory) technique to analyse cell signalling dynamics during zebrafish spinal cord development. This approach reveals that Notch and Hh signalling display similar spatiotemporal kinetics throughout spinal cord patterning. Notch signalling functions upstream to control Hh response of neural progenitor cells. Using gain- and loss-of-function tools, we demonstrate that this regulation occurs not at the level of upstream regulators or primary cilia, but rather at the level of Gli transcription factors. Our results indicate that Notch signalling maintains Hh responsiveness of neural progenitors via a Gli-dependent mechanism in the spinal cord.
Reference Key
jacobs2019notchelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jacobs, Craig T;Huang, Peng;
Journal eLife
Year 2019
DOI
10.7554/eLife.49252
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Keywords Keywords not found

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