cell–cell interaction proteins (gap junctions, tight junctions, and desmosomes) and water transporter aquaporin 4 in meningothelial cells of the human optic nerve

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ID: 196480
2017
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Abstract
PurposeMeningothelial cells (MECs) play a central role in the maintenance of cerebrospinal fluid (CSF) homeostasis and in physiological and pathophysiological processes within the subarachnoid space (SAS) linking them to optic nerve (ON) pathologies. Still, not much is known about their structural properties that might enable MECs to perform specific functions within the ON microenvironment.MethodsFor closer characterization of the structural properties of the human MEC layer in the arachnoid, we performed immunohistological analyses to evaluate the presence of cell–cell interaction markers, namely, markers for tight junctions (JAM1, Occludin, and Claudin 5), gap junctions (Connexin 26 and 43), and desmosomes (Desmoplakin) as well as for water channel marker aquaporin 4 (AQP4) in retrobulbar, midorbital, and intracanalicular human ON sections.ResultsMECs displayed immunopositivity for markers of tight junctions (JAM1, Occludin, and Claudin 5) and gap junctions (Connexin 26 and 43) as well as for AQP4 water channels. However, no immunopositivity was found for Desmoplakin.ConclusionMECs are connected via tight junctions and gap junctions, and they possess AQP4 water channels. The presence of these proteins emphasizes the important function of MECs within the ON microenvironment as part of the meningeal barrier. Beyond this barrier function, the expression of these proteins by MECs supports a broader role of these cells in signal transduction and CSF clearance pathways within the ON microenvironment.
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zeleny2017frontierscellcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Thi Ngoc Co Zeleny;Corina Kohler;Corina Kohler;Albert Neutzner;Albert Neutzner;Hanspeter E. Killer;Hanspeter E. Killer;Peter Meyer;Peter Meyer
Journal journal of photochemistry and photobiology a: chemistry
Year 2017
DOI
10.3389/fneur.2017.00308
URL
http://journal.frontiersin.org/article/10.3389/fneur.2017.00308/full
Keywords
optic nerve degeneration diseases of the nervous system

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