genetic polymorphisms of nat2, cyp2e1 and gst enzymes and the occurrence of antituberculosis drug-induced hepatitis in brazilian tb patients
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ID: 196417
2011
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Abstract
Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibility factors to anti-TB drug-induced hepatitis in Brazilian individuals. In a case-control design, 167 unrelated active tuberculosis patients from the University Hospital of the Federal University of Rio de Janeiro, Brazil, were enrolled in this study. Patients with a history of anti-TB drug-induced acute hepatitis (cases with an increase to 3 times the upper limit of normal serum transaminases and symptoms of hepatitis) and patients with no evidence of anti-TB hepatic side effects (controls) were genotyped for NAT2, CYP2E1, GSTM1 and GSTT1 polymorphisms. Slow acetylators had a higher incidence of hepatitis than intermediate/rapid acetylators [22% (18/82) vs. 9.8% (6/61), odds ratio (OR), 2.86, 95% confidence interval (CI), 1.06-7.68, p = 0.04). Logistic regression showed that slow acetylation status was the only independent risk factor (OR 3.59, 95% CI, 2.53-4.64, p = 0.02) for the occurrence of anti-TB drug-induced hepatitis during anti-TB treatment with INH-containing schemes in Brazilian individuals.
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teixeira2011memriasgenetic
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| Authors | ;Raquel Lima de Figueiredo Teixeira;Renata Gomes Morato;Pedro Hernan Cabello;Ligia Mayumi Kitada Muniz;Adriana da Silva Rezende Moreira;Afrânio Lineu Kritski;Fernanda Carvalho Queiroz Mello;Philip Noel Suffys;Antonio Basilio de Miranda;Adalberto Rezende Santos |
| Journal | kurdistan journal of applied research |
| Year | 2011 |
| DOI |
10.1590/S0074-02762011000600011
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| URL | |
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