effect of aminophenyl and aminothiahexyl α-d-glycosides of the manno-, gluco-, and galacto-series on type 1 fimbriae-mediated adhesion of escherichia coli

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ID: 196280
2013
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Abstract
Adhesion of bacteria to the glycosylated surface of their target cells is typically mediated by fimbrial lectins, exposed on the bacterial surface. Among the best-investigated and most important fimbriae are type 1 fimbriae, for which α-d-mannopyranoside-specificity has been described. This carbohydrate specificity is mediated by the type 1 fimbrial lectin FimH. In this account, we have employed four different set-ups to assay type 1 fimbriae-mediated bacterial adhesion, including tailor-made glycoarrays. The focus of our study was on testing FimH specificity with regard to the glycone part of a glycosidic ligand by testing a series of synthetic α-mannosides, as well as α-glucosides and α-galactosides. Unexpectedly, it was found that in solution all tested aminothiahexyl glycosides inhibit bacterial adhesion but that this effect is unspecific. Instead it is due to cytotoxicity of the respective glycosides at high mm concentrations.
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lindhorst2013biologyeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Thisbe K. Lindhorst;Claudia Fessele
Journal Journal of microencapsulation
Year 2013
DOI
10.3390/biology2031135
URL
http://www.mdpi.com/2079-7737/2/3/1135
Keywords
bacterial adhesion adhesion-inhibition assays

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