establishment of a mast cell line, ncl-2, without kit mutation, derived from nc mouse bone marrow
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2014
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Abstract
Immortal mast cell lines, such as RBL-2H3 and HMC-1 cells, are commonly utilized to investigate the function of mast cells. However, they are tumor cells carrying a gain-of-function mutation of Kit. We established an immortal mast cell line without Kit mutation, NCL-2, derived from NC mouse bone marrow. NCL-2 cells could be maintained without additional growth factors and thus could respond to exogenous growth signals. Moreover, NCL-2 cells expressed FcεRI and KIT, and release histamine and LTB4 in response to antigen stimulation. This cell line could be a useful tool to analyze proliferation, differentiation, and function of normal mast cells.
| Reference Key |
hiragun2014febsestablishment
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|---|---|
| Authors | ;Takaaki Hiragun;Yuhki Yanase;Tsutomu Okabe;Makiko Hiragun;Mikio Kawai;Michihiro Hide |
| Journal | journal of ayub medical college, abbottabad : jamc |
| Year | 2014 |
| DOI |
10.1016/j.fob.2014.03.011
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