revisitation of an old antimalarial to combat psoriatic arthritis administering an antidote to santonin to avoid xanthopsia or maculopathy

Background: The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is hitherto unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Material and Methods: Patient with psoriatic artritis after ineffective therapy of three kinds of NSAIDs was used following therapy: chloroquine: 250 mg/day for one entire year; -ibuprofene: 600 mg/day for one entire year; thiamine: 1.6 mg/day. Was analyzed of Disease Activity Score (Das28 using three parameters, excluding the self evaluation, because of the problem of the subjectivity according to the method heralded by Van der Heijde DMFM, van’t Hof MA, van Riel PLCM, van de Putte LBA. Results: At the beginning Das28 was 2.4 and at the end of the trial it was 1.00. Conclusions: The antidotes to santonine are limewater, chloral hydrate and thiamine. The antidotes Forecasts a novel re-introduction of this antimalarial in therapy against RA as it reveals a good improvement according to the Das28 method of evaluation of remission of complex symptoms of the same Reumatoid Arthritis.