the impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis
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2012
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Abstract
Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol.
Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2×70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1±2.6 versus 3.8±2.4
litre, 𝑃<0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4±7.4
versus 13±7.6 litre, 𝑃=0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly.
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| Reference Key |
bethlehem2012criticalthe
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|---|---|
| Authors | ;Carina Bethlehem;Frouwke M. Groenwold;Hanneke Buter;W. Peter Kingma;Michael A. Kuiper;Fellery de Lange;Paul Elbers;Henk Groen;Eric N. van Roon;E. Christiaan Boerma |
| Journal | Chemosphere |
| Year | 2012 |
| DOI |
10.1155/2012/161879
|
| URL | |
| Keywords |
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