the association of cd81 polymorphisms with alloimmunization in sickle cell disease

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ID: 196016
2013
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Abstract
The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD). Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization. Biomarker(s) which predicts (predict) susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have important implications for clinical management. In addition, such markers could shed light on the mechanism(s) underlying alloimmunization. We genotyped 27 single nucleotide polymorphisms (SNPs) in the CD81, CHRNA10, and ARHG genes in two groups of SCD patients. One group (35) of patients developed alloantibodies, and another (40) had no alloantibodies despite having received multiple transfusions. Two SNPs in the CD81 gene, that encodes molecule involved in the signal modulation of B lymphocytes, show a strong association with alloimmunization. If confirmed in prospective studies with larger cohorts, the two SNPs identified in this retrospective study could serve as predictive biomarkers for alloimmunization.
Reference Key
tatari-calderone2013clinicalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Zohreh Tatari-Calderone;Ryad Tamouza;Gama P. Le Bouder;Ramita Dewan;Naomi L. C. Luban;Jacqueline Lasserre;Jacqueline Maury;François Lionnet;Rajagopal Krishnamoorthy;Robert Girot;Stanislav Vukmanovic
Journal Applied Surface Science
Year 2013
DOI
10.1155/2013/937846
URL
http://dx.doi.org/10.1155/2013/937846
Keywords
immunologic diseases allergy

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