fatal and near-fatal non-allergic reactions in patients with underlying cardiac disease receiving benzathine penicillin g in israel and switzerland

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ID: 195923
2017
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Abstract
Benzathine Penicillin G (BPG) is commonly used for treatment of penicillin-susceptible infections and secondary prevention of rheumatic fever. Death following administration of BPG is extremely rare—only a handful of cases have been described in the literature since the 1950's. In this case series from Israel and Switzerland, we describe nine cases of serious adverse reactions—six fatal reactions and three near-fatalities—occurring within minutes of receiving intramuscular BPG. Allergic reactions or faulty administration were not implicated in any of the cases; however, all patients had cardiac risk factors. This case series describes a relatively rare risk that should be borne in mind when prescribing BPG.
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berkovitch2017frontiersfatal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Matitiahu Berkovitch;Matitiahu Berkovitch;Liat Ashkenazi-Hoffnung;Liat Ashkenazi-Hoffnung;Ilan Youngster;Ilan Youngster;Dotan Shaniv;Dotan Shaniv;Dorit Dil-Nahlieli;Einat Gorelik;Martina Schäublin;Rudolf Stoller;Nour Karra;Nour Karra;Eyal Schwartzberg;Eyal Schwartzberg
Journal chemical research in chinese universities
Year 2017
DOI
10.3389/fphar.2017.00843
URL
http://journal.frontiersin.org/article/10.3389/fphar.2017.00843/full
Keywords
death penicillin pharmacology

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