turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells
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ID: 195903
1992
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Abstract
We have studied the effect of human recombinant tumour necrosis factor-α (TNF-α) on gene expression and production of endothelin-1 in cultured bovine aortic endothelial cells. TNF-α (10 and 100 ng ml−1) increased in a time dependent manner the preproendothelin-1 mRNA levels in respect to unstimulated endothelial cells. TNF-α induced endothelin-1 gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium. These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.
| Reference Key |
orisio1992mediatorsturnour
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|---|---|
| Authors | ;Silvia Orisio;Marina Morigi;Carla Zoja;Norberto Perico;Giuseppe Remuzzi |
| Journal | polyhedron |
| Year | 1992 |
| DOI |
10.1155/S0962935192000401
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| URL | |
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