intoxicaÇÃo por disofenol em caprinos poisoning by disophenol in goats

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ID: 195802
2001
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Abstract
Cinqüenta e seis cabras morreram em aproximadamente 44 horas após serem medicadas com disofenol. Dois animais foram necropsiados. Pontos de coloração marrom claro, com aproximadamente 2cm de diâmetro foram observados na cápsula e superfície de corte do órgão. A superfície de corte dos rins apresentaram áreas claras intercaladas com áreas escuras. A bexiga urinária estava repleta com urina e sedimento. A cavidade abdominal, torácica e o saco pericárdico tinham acúmulo de fluído amarelado. Espuma foi encontrada na traquéia e pulmões. Metabolização da gordura coronariana e mesentérica também foi observada. As lesões histológicas caracterizaram-se por necrose centrolobular ou massiva do fígado; necrose do epitélio dos túbulos, com presença de cilindros e congestão nos rins; e edema do pulmão. Em quatro cabras, foi aplicado por via subcutânea disofenol a doses de 10, 10,5, 19,04 e 29,43mg por kg de peso vivo. O caprino que recebeu 10,5mg/kg foi mantido em uma sala à temperatura de aproximadamente 28ºC durante 18 horas. O caprino que recebeu 29,43mg/kg morreu. Os achados macroscópicos e histológicos foram similares aos observados na intoxicação espontânea.
Fifty-six goats died approximately 44 hours after been medicated with disophenol. Two animals were necropsied. Brown spots of approximately 2cm were observed in the capsule and cut surface of the liver. The cut surface of the kidneys presented clear areas mixed with dark areas. The urinary bladder was replete with urine and sediment. The abdominal, toracic and pericardic cavities had accumulation of yellow fluid. Edema was found in the trachea and lung. Metabolization of the coronary and mesenteric fat was also observed. Histologic lesions were characterized by centrilobular or diffuse necrosis of the liver; necrosis of the epitelial tubules, with presence of cilinders and congestion in the kidneys; and edema of the lung. Four goats were inoculated subcutaneously with 10, 10.5, 19.04 and 29.43mg per kg body weight of disophenol. The animal treated with 10.5mg/kg was mantained during 18 hours at room with temperature of 28ºC. The goat that recieved 29.43 mg/kg died. The macroscopic and histologic findings were similar to those observed in the spontaneous case.
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Authors ;Mauro Pereira Soares;Fernando Sergio Castilhos Karam;Gisele Braziliano de Andrade
Journal Trials
Year 2001
DOI
10.1590/S0103-84782001000100026
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782001000100026
Keywords
poisoning

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