Neurogenetic dissection of the lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.

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ID: 1957
2019
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Abstract
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In , one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic tools for this region. We generate a collection of split-GAL4 driver lines providing genetic access to 82 LH cell types. We use these to create an anatomical and neurotransmitter map of the LH and link this to EM connectomics data. We find ~30% of LH projections converge with outputs from the mushroom body, site of olfactory learning and memory. Using optogenetic activation, we identify LH cell types that drive changes in valence behavior or specific locomotor programs. In summary, we have generated a resource for manipulating and mapping LH neurons, providing new insights into the circuit basis of innate and learned olfactory behavior.
Reference Key
dolan2019neurogeneticelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dolan, Michael-John;Frechter, Shahar;Bates, Alexander Shakeel;Dan, Chuntao;Huoviala, Paavo;Roberts, Ruairí Jv;Schlegel, Philipp;Dhawan, Serene;Tabano, Remy;Dionne, Heather;Christoforou, Christina;Close, Kari;Sutcliffe, Ben;Giuliani, Bianca;Li, Feng;Costa, Marta;Ihrke, Gudrun;Meissner, Geoffrey Wilson;Bock, Davi D;Aso, Yoshinori;Rubin, Gerald M;Jefferis, Gregory Sxe;
Journal eLife
Year 2019
DOI
10.7554/eLife.43079
URL
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