síntese e avaliação preliminar da atividade antibacteriana e antifúngica de derivados n-acilidrazônicos
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ID: 195577
2012
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Abstract
We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.
| Reference Key |
cachiba2012qumicasntese
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|---|---|
| Authors | ;Thomas Haruo Cachiba;Bruno Demartini Carvalho;Diogo Teixeira Carvalho;Marina Cusinato;Clara Gavião Prado;Amanda Latercia Tranches Dias |
| Journal | greece and rome |
| Year | 2012 |
| DOI |
10.1590/S0100-40422012000800014
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| URL | |
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