gram-negative bacterial lipopolysaccharide stimulates activin a secretion from human amniotic epithelial cells
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2013
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Abstract
Activin A is involved in inflammation. The present study was performed to clarify if lipopolysaccharide, a component of Gram-negative bacteria, stimulates activin A secretion from human amniotic epithelial cells and to determine if activin A plays a role in amnionitis. Fetal membranes were obtained during elective cesarean sections performed in full-term pregnancies of patients without systemic disease, signs of premature delivery, or fetal complications. Amniotic epithelial cells were isolated by trypsinization. The activin A concentrations in the culture media were measured by enzyme-linked immunosorbent assay, and cell proliferation was assessed by 5-bromo-2′-deoxyuridine incorporation. Amniotic epithelial cells secreted activin A in a cell density-dependent manner, and lipopolysaccharide (10 μg/mL) enhanced the secretion at each cell density. Lipopolysaccharide (10–50 μg/mL) also stimulated activin A secretion in a dose-dependent manner. Contrary to the effect of activin A secretion, lipopolysaccharide inhibited cell proliferation in amniotic epithelial cells. The present study suggests that lipopolysaccharide stimulation of activin A secretion may be a mechanism in the pathogenesis of amnionitis.
| Reference Key |
abe2013internationalgram-negative
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|---|---|
| Authors | ;Yumiko Abe;Risa Marukawa;Nami Tsuru;Maki Sato;Hiroko Matsuda;Hisanobu Sadakata;Takashi Kameda;Takashi Minegishi |
| Journal | zhonghua wei zhong bing ji jiu yi xue |
| Year | 2013 |
| DOI |
10.1155/2013/789012
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| URL | |
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