mbd2 and mbd3: elusive functions and mechanisms

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ID: 195320
2014
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Abstract
DNA methylation is a long known epigenetic mark involved in many biological processes and the ‘readers’ of this mark belong to several distinct protein families that ‘read’ and ‘translate’ the methylation mark into a function. Methyl-CpG binding domain proteins belong to one of these families that are associated with transcriptional activation/repression, regulation of chromatin structure, pluripotency, development and differentiation. Discovered decades ago, the systematic determination of the genomic binding sites of these readers and their epigenome make-up at a genome-wide level revealed the tip of the functional iceberg. This review focuses on two members of the methyl binding proteins, namely MBD2 and MBD3 that reside in very similar complexes, yet appear to have very different biological roles. We provide a comprehensive comparison of their genome-wide binding features and emerging roles in gene regulation.
Reference Key
emenafra2014frontiersmbd2 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Roberta eMenafra;Hendrik G Stunnenberg
Journal chemical record (new york, ny)
Year 2014
DOI
10.3389/fgene.2014.00428
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00428/full
Keywords
dna methylation chromatin immunoprecipitation transcription regulation

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