pigment epithelium-derived factor (pedf) is a determinant of stem cell fate: lessons from an ultra-rare disease

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2015
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Abstract
PEDF is a secreted glycoprotein that is widely expressed by multiple organs. Numerous functional contributions have been attributed to PEDF with antiangiogenic, antitumor, anti-inflammatory, and neurotrophic properties among the most prominent. The discovery that null mutations in the PEDF gene results in Osteogenesis Imperfecta Type VI, a rare autosomal recessive bone disease characterized by multiple fractures, highlights a critical developmental function for this protein. This ultra-rare orphan disease has provided biological insights into previous studies that noted PEDF’s effects on various stem cell populations. In addition to bone development, PEDF modulates resident stem cell populations in the brain, muscle, and eye. Functional effects on human embryonic stem cells have also been demonstrated. An overview of recent advances in our understanding by which PEDF regulates stem cells and their potential clinical applications will be evaluated in this review.
Reference Key
sagheer2015journalpigment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Usman Sagheer;Jingjing Gong;Chuhan Chung
Journal journal of counseling psychology
Year 2015
DOI
10.3390/jdb3040112
URL
http://www.mdpi.com/2221-3759/3/4/112
Keywords
stem cells pigment epithelium-derived factor

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