copa3 peptide from copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway
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2012
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Abstract
Our previous study demonstrated that CopA3, a disulfide dimerof the coprisin peptide analogue (LLCIALRKK), has antibacterialactivity. In this study, we assessed whether CopA3caused cellular toxicity in various mammalian cell lines.CopA3 selectively caused a marked decrease in cell viabilityin Jurkat T, U937, and AML-2 cells (human leukemia cells),but was not cytotoxic to Caki or Hela cells. Fragmentation ofDNA, a marker of apoptosis, was also confirmed in the leukemiacell lines, but not in the other cells. CopA3-induced apoptosisin leukemia cells was mediated by apoptosis inducingfactor (AIF), indicating induction of a caspase-independent signalingpathway. [BMB reports 2012; 45(2): 85-90]
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| Reference Key |
kang2012bmbcopa3
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|---|---|
| Authors | ;Bo Ram Kang;Ho Kim;Sung-Hee Nam;Eun-Young Yun;Seong-Ryul Kim;Mi-Young Ahn;Jong Soo Chang;Jae Sam Hwang |
| Journal | canadian journal of physiology and pharmacology |
| Year | 2012 |
| DOI |
http://dx.doi.org/10.5483/BMBRep.2012.45.2.85
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