genetic background and expression of the new qepa4 gene variant recovered in clinical tem-1- and cmy-2-producing escherichia coli
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ID: 194671
2017
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Abstract
A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.
| Reference Key |
manageiro2017frontiersgenetic
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| Authors | ;Vera Manageiro;Vera Manageiro;David Félix;Daniela Jones-Dias;Daniela Jones-Dias;Daniel A. Sampaio;Luís Vieira;Luísa Sancho;Eugénia Ferreira;Manuela Caniça |
| Journal | journal of magnetic resonance (san diego, calif : 1997) |
| Year | 2017 |
| DOI |
10.3389/fmicb.2017.01899
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